Various options and actions are available via use of the keyboard, as follows:
| F1 Help | Help (later simulations) |
| F2 Train List | Opens the Train List Window |
| F3 Options | Opens the Options Menu |
| F4 Timetable Editor | Opens the Timetable Editor |
| F5 Scoring | Shows the points scoring |
| F6 Telephone Calls | Allows phone calls to be made and answered |
| F7 Incident Report | Displays details of incidents, failures, and other delays |
| F8 Simplifier | Opens the Simplifier - shows due trains at a particular location |
| F10 Send Message | Allows sending of messages to other players (Multiplay and chained simulations only) |
| F11 Incident Control Panel | Allows control of degraded working (March 2010 onwards) |
And the following - in lower case
| A | Answer the first telephone call |
| I | TD interpose |
| N | Set to run at normal (real time) speed |
| + (on numeric keypad) | Increase simulation speed |
| - (on numeric keypad) | Decrease simulation speed |
| F | Run simulation fast for five simulation minutes |
| P | Pause/unpause |
| S | Save simulation |
In addition to this, any sim may include one or more location hotkeys, invoked by pressing a number from 0 to 9, or Shift+[hotkey letter]. E.g., in the Swindon A and B sim, pressing Shift+D centres the sim on Didcot Station. See Hot keys